Studies related to Heart Rate and Ephedrine

Herbal Ephedra/caffeine For Weight Loss: A 6-month Randomized Safety And Efficacy Trial

Effect Increase
Trial Design Double blind
Trial Length n/a
Number of Subjects 167
Gender n/a
Notes for this study:
Over a period of 6 months, ephedrine/caffeine at 90mg/192mg daily (from Ma Huang and Kola Nut) reduced body weight by 5.6kg while placebo induced 2.6kg weight loss.

LDL cholesterol was reduced by 8mg/dl in EC group and HDL cholesterol increased by 2.7mg/dl. Placebo did not see changes.

Small increases in blood pressure and heart rate were seen, but of minor significance. Compliance was similar in both groups.

Enhanced Thermogenic Responsiveness During Chronic Ephedrine Treatment In Man

Effect None
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 5
Gender Female
Age Range 18-29, 30-44, 45-64
Body Types Overweight
Notes for this study:
As assessed by oxygen consumption, metabolic rate was significantly increased in 5 overweight females (Body fat % around 30-33, one at 38). Ephedrine boluses were given as tests (1mg/kg bodyweight) but a standard 20mg three times a day treatment was given chronically.

Average weight loss was 2.5kg after 4 weeks and 5.5kg after 12 weeks, losing 3.5-5.3% of their body fat (range of averages).

Blood pressure increased 1 hour (23mmHg after bolus, 5mmHg during treatment) after consumption of ephedrine, but declined to baseline.

Efficacy And Safety Of Single And Multiple Doses Of Pseudoephedrine In The Treatment Of Nasal Congestion Associated With Common Cold

Effect Increase
Trial Design Double blind
Trial Length n/a
Number of Subjects 238
Gender n/a
Notes for this study:
One of the ephedrine alkaloids, pseudoephedrine, was found to be effective in nasal decongestion in a group of healthy persons with nasal congestion associated with the common cold.

Heart rate was elevated 2-4 beats per minute, clinically insignificant but statistically relevant.

Adverse effects were not related to treatment.

A Randomized Double-blind Placebo-controlled Clinical Trial Of A Product Containing Ephedrine, Caffeine, And Other Ingredients From Herbal Sources For Treatment Of Overweight And Obesity In The Absence Of Lifestyle Treatment

Effect None
Trial Design Double blind
Trial Length n/a
Number of Subjects 102
Gender n/a
Notes for this study:
Over a period of 12 weeks, obese persons between the ages of 18-65.

At the end of 12 weeks, the experimental group had less body fat and BMI with no long-term changes in blood pressure or heart rate.

The benefits seen were independent of any changes to lifestyle.

Multinutrient Supplement Containing Ephedra And Caffeine Causes Weight Loss And Improves Metabolic Risk Factors In Obese Women: A Randomized Controlled Trial

Effect Decrease
Trial Design Double blind
Trial Length n/a
Number of Subjects 61
Gender n/a
Notes for this study:
Over a period of 9 months, a supplement containing ephedra was associated with a loss of 7.18kg relative to placebo's 2.25kg. With the weight loss came improvements in various blood parameters.

*Study highly confounded with lack of dietary control and Garcinia cambogia usage*