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Apolipoprotein A

Apolipoprotein A is the apolipoprotein for HDL cholesterol, and increasing its concentrations promotes flux of fatty acids and molecules that are carried on lipoproteins away from peripheral tissue and towards the liver.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect apolipoprotein a
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Red Clover Extract - High See all 4 studies
A large decrease has been noted in one study in overweight postmenopausal women, although three other studies failed to replicate this decrease.
grade-c Ginkgo biloba Minor - See study
In high risk individuals, the reduction has been noted to be 23.4+/-7.9%
grade-c Trimethylglycine Minor - See study
An increase in Apolipoprotein A1 has been noted with supplementation of betaine relative to placebo in otherwise healthy persons.
grade-c Vitamin B3 (Niacin)  
grade-c Zinc  
grade-c Astaxanthin  
grade-c Chromium  
grade-c Fish Oil  
grade-c Hesperidin  
grade-c Lactobacillus reuteri  
grade-d Krill Oil  
grade-d Hibiscus sabdariffa  
grade-d Medium-chain triglycerides  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.