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Chronic Venous Insufficiency

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Chronic Venous Insufficiency

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Chronic Venous Insufficiency

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect chronic venous insufficiency
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 8 studies
Symptoms of chronic venous insufficiency extending to poor circulation, venous reactivity, and adverse side-effects such as edema and leg pain are all reliably reduced with oral ingestion of centella asiatica
grade-b Notable Very High See all 3 studies
Due to the venotrophic effects of aescin supplementation, disease states associated with blood pooling in extremities are significantly and fairly reliably treated with horse chestnut.
grade-c Minor - See study
Ruscus aculeatus appears to be more effective than placebo for treating chronic venous insufficiency, although the degree of benefit relative to other treatments is not established.

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grade-d