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Exercise Capacity (with Heart Conditions)

Cardiovascular exercise is known to be impaired in persons with heart disorders and supplements are being investigated to see whether the performance enhancing effects in healthy subjects can be extended to these persons.

Kamal Patel
Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect exercise capacity (with heart conditions)
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Coenzyme Q10 Minor Very High See all 4 studies
Appears to aid exercise capacity in persons after myocardial infarction
grade-b Creatine - Very High See all 3 studies
Although there may be a small reduction of power output (typical of creatine), the main parameter of interest (cardiorespiratory output) is mostly unaffected by creatine supplementation.
grade-c Berberine Minor - See study
A positive effect, but the potency thereof was not overly remarkable
grade-c Glutamine  
grade-d Citrulline  
grade-d Garlic  
grade-d Taurine  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.

This page is regularly updated, to include the most recently available clinical trial evidence.

Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process.

This page features 0 references. All factual claims are followed by specifically-applicable references. Click here to see the full set of references for this page.

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