Quick Navigation

Interleukin 6

Interleukin 6 (IL-6) is a proinflammatory cytokine that is thought to reflect a more inflammatory state in the body.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Things To Know & Note

Also Known As


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect interleukin 6
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Curcumin Minor - See study
A slight decrease in IL-6 concentrations has been noted, practical relevance unknown.
grade-c Fish Oil Minor - See study
A decrease in circulating IL-6 has been noted with fish oil supplementation
grade-c Ginkgo biloba Minor - See study
A slight reduction in IL-6 has been reported in persons who are diagnosed with metabolic syndrome
grade-c Zinc  
grade-c Alanylglutamine  
grade-c Blueberry  
grade-c Cocoa Extract  
grade-c Colostrum  
grade-c Garlic  
grade-c HMB  
grade-c Hesperidin  
grade-c Lactobacillus reuteri  
grade-c Quercetin  
grade-c Vitamin B3 (Niacin)  
grade-c Vitamin C  
grade-c Vitamin E  
grade-c Vitamin K  
grade-d Iodine  
grade-d Pyrroloquinoline quinone  
grade-d Conjugated Linoleic Acid  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.