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Lactate Production

Lactate can be produced during prolonged exercise, and while it is not thought to contribute to muscular failure it seems to be a good biomarker of it. Reductions in lactate production tend to be associated with prolonged physical endurance.

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect lactate production
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-a Sodium Bicarbonate
- See all 37 studies
Increases of lactate production are noted in short intense exercises (due to allowing more work to be conducted, and the work produces more lactate) while prolonged exercise is associated with a decrease in lactate concentrations relative to placebo
grade-b Caffeine Minor Very High See all 6 studies
Seems to increase lactate production during exercise when caffeine is acutely preloaded
grade-b L-Carnitine Minor Moderate See all 5 studies
Lactate production appears to be decreased in studies that note an increase in muscular carnitine stores, although the decrease is not overly notable
grade-b Branched Chain Amino Acids  
grade-b Colostrum  
grade-b Creatine  
grade-b Trimethylglycine  
grade-c Chromium  
grade-c Panax ginseng  
grade-c Rhodiola Rosea  
grade-c Alanylglutamine  
grade-c Arginine  
grade-c Astaxanthin  
grade-c Citrulline  
grade-c Vitamin E  
grade-c Yerba mate  
grade-d Cocoa Extract  
grade-d Phosphatidylserine  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.