Quick Navigation

Liver Enzymes

Liver enzymes are a commonly used biomarker to test the toxicity of a supplement, and are elevated in instances of fatty or cirrhotic livers. Their reduction in the blood is thought to reflect less damage to liver cells.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect liver enzymes
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Tauroursodeoxycholic Acid Notable Very High See all 5 studies
The decrease in liver enzymes associated with cholestasis is quite strong, and TUDCA is a reference drug for these effects
grade-b Vitamin E Notable Low See all 9 studies
There appears to be a notable decrease in both ALT and γ-GPT in persons with non-alcoholic fatty liver (NAFLD) which may exceed 50% when vitamin E is supplemented above 300mg for half a year; there does not appear to be any influence whatsoever in healthy controls.
grade-b Trimethylglycine Minor Low See all 5 studies
Similar to liver fat and damage, the levels of liver enzymes in serum appears to be reduced potently in preliminary evidence with the currently largest trial showing no significant influence; there may be a role, but it needs to be further elucidated.
grade-b Chromium  
grade-b Conjugated Linoleic Acid  
grade-b Creatine  
grade-b Lactobacillus reuteri  
grade-b Nigella sativa  
grade-c Fucoxanthin  
grade-c Artichoke Extract  
grade-c Garlic  
grade-c Gynostemma pentaphyllum  
grade-c Hesperidin  
grade-c Hoodia gordonii  
grade-c L-Carnitine  
grade-c Melatonin  
grade-c Picrorhiza kurroa  
grade-c Resveratrol  
grade-c Anethum graveolens  
grade-c Astaxanthin  
grade-c Citrulline  
grade-c Citrullus colocynthis  
grade-c Cordyceps  
grade-c Curcumin  
grade-c Dehydroepiandrosterone  
grade-c Ecdysteroids  
grade-c Eleutherococcus senticosus  
grade-c Fish Oil  
grade-c Ganoderma lucidum  
grade-c Glutamine  
grade-c Green Coffee Extract  
grade-c HMB  
grade-c Inositol  
grade-c Kava  
grade-c Leucine  
grade-c Nattokinase  
grade-c Olive leaf extract  
grade-c Phosphatidylserine  
grade-c Pterostilbene  
grade-c Red Clover Extract  
grade-c Rose Hip  
grade-c S-Adenosyl Methionine  
grade-c Saffron  
grade-c Vitamin B3 (Niacin)  
grade-d Spirulina  
grade-d Andrographis paniculata  
grade-d Hibiscus sabdariffa  
grade-d Rubus coreanus  
grade-d Whey Protein  
grade-d Ashwagandha  
grade-d Black Cohosh  
grade-d Bulbine natalensis  
grade-d Cocoa Extract  
grade-d Perilla Oil  
grade-d Pyrroloquinoline quinone  
grade-d Royal Jelly  
grade-d Terminalia arjuna  
grade-d Tetradecyl Thioacetic Acid  
grade-d Tribulus terrestris  
grade-d Vitamin C  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.