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Muscle Oxygenation

Muscle oxygenation is the rate of oxygen usage and supply to a working muscle tissue. This is usually tied in with nitric oxide metabolism, and increased muscle oxygenation should lead to increased anaerobic muscle performance.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect muscle oxygenation
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Magnesium Notable - See study
The one study to measure muscle oxygenation in high intensity exercise noted quite a remarkable increase in oxygenation in healthy athletes; this needs to be replicated
grade-c L-Carnitine Minor - See study
A decrease in muscle oxygenation has been noted during occlusion, but not during squat exercise; practical significance of these results unknown
grade-c Sodium Bicarbonate Minor - See study
The rate of muscle deoxygenation is reduced with attenuation of acidosis (which can be achieved with sodium bicarbonate), and in later stretches of exercise this can be manifest as a relative increase in oxygenation
grade-c Trimethylglycine  
grade-c Creatine  
grade-c Rhodiola Rosea  
grade-d Citrulline  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.