How does muscle gain work?

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    Last Updated: October 13, 2024

    Muscle tissue is constantly turning over, with the rates of muscle protein synthesis (MPS) and muscle protein breakdown (MPB) fluctuating throughout the day. Net protein balance is the difference between MPS and MPB. For an increase in muscle mass to occur, MPS must exceed MPB, resulting in a positive net protein balance.[1] MPS is very sensitive to exercise and diet (namely, essential amino acid intake).