The exact cause of AAMCD is unknown. One hypothesis is that the decline in cognitive function is related to reduced brain matter, specifically white matter. After the age of 70, there is a pronounced reduction in white matter volume. Other potential mechanisms that may play a role in the development of AAMCD are mitochondrial dysfunction, neurotransmitter alterations, chronic inflammation, high levels of stress-related corticosteroids, high blood pressure, vascular changes associated with aging, and oxidative stress.[1][2][3]
References
- ^Deary et al.Age-associated cognitive declineBr. Med. Bull..(2009-12-01)
- ^Harada CN, Natelson Love MC, Triebel KLNormal cognitive aging.Clin Geriatr Med.(2013-Nov)
- ^Lee J, Kim HJNormal Aging Induces Changes in the Brain and Neurodegeneration Progress: Review of the Structural, Biochemical, Metabolic, Cellular, and Molecular Changes.Front Aging Neurosci.(2022)