Examine Database: Amyotrophic Lateral Sclerosis
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Does altering the gut microbiome improve motor symptoms in the context of neurodegenerative disease?
In this meta-analysis of clinical trials, interventions that altered the gut microbiome improved motor symptoms in participants with neurodegenerative disease, but many different interventions were used and the quality of evidence was poor.
Examine Database References
- Kidney Function - Groeneveld GJ, Veldink JH, van der Tweel I, Kalmijn S, Beijer C, de Visser M, Wokke JH, Franssen H, van den Berg LHA randomized sequential trial of creatine in amyotrophic lateral sclerosisAnn Neurol.(2003 Apr)
- Kidney Function - Shefner JM, Cudkowicz ME, Schoenfeld D, Conrad T, Taft J, Chilton M, Urbinelli L, Qureshi M, Zhang H, Pestronk A, Caress J, Donofrio P, Sorenson E, Bradley W, Lomen-Hoerth C, Pioro E, Rezania K, Ross M, Pascuzzi R, Heiman-Patterson T, Tandan R, Mitsumoto H, Rothstein J, Smith-Palmer T, MacDonald D, Burke D; NEALS ConsortiumA clinical trial of creatine in ALSNeurology.(2004 Nov 9)
- Kidney Function - Groeneveld GJ, Beijer C, Veldink JH, Kalmijn S, Wokke JH, van den Berg LHFew adverse effects of long-term creatine supplementation in a placebo-controlled trialInt J Sports Med.(2005 May)
- Lung Function - Rosenfeld J, King RM, Jackson CE, Bedlack RS, Barohn RJ, Dick A, Phillips LH, Chapin J, Gelinas DF, Lou JSCreatine monohydrate in ALS: effects on strength, fatigue, respiratory status and ALSFRSAmyotroph Lateral Scler.(2008 Oct)
- Lung Function - Mazzini L, Balzarini C, Colombo R, Mora G, Pastore I, De Ambrogio R, Caligari MEffects of creatine supplementation on exercise performance and muscular strength in amyotrophic lateral sclerosis: preliminary resultsJ Neurol Sci.(2001 Oct 15)
- Lung Function - Drory VE, Gross DNo effect of creatine on respiratory distress in amyotrophic lateral sclerosisAmyotroph Lateral Scler Other Motor Neuron Disord.(2002 Mar)
- Amyotrophic Lateral Sclerosis Symptoms - Pastula DM, Moore DH, Bedlack RSCreatine for amyotrophic lateral sclerosis/motor neuron diseaseCochrane Database Syst Rev.(2012 Dec 12)