What causes ankylosing spondylitis?

    Researchedby:
    Henry Wideman

    Fact-checked

    by:

    Nick Milazzo
    Last Updated: October 25, 2023

    Although the cause of AS is unknown, genetics play a large role in an individual’s susceptibility. In particular, the human leukocyte antigen HLA-B27 is strongly correlated with AS.[1] Men are more likely to present with the radiographic signs of AS, but spondyloarthritis occurs with a more even frequency.[2] The absence of radiographic indications among women can result in a diagnostic delay, during which time the disease can progress unmanaged.[3]

    References

    1. ^Reveille JDThe genetic basis of ankylosing spondylitis.Curr Opin Rheumatol.(2006-Jul)
    2. ^Gran JT, Husby GAnkylosing spondylitis in women.Semin Arthritis Rheum.(1990-Apr)
    3. ^Rusman T, van Vollenhoven RF, van der Horst-Bruinsma IEGender Differences in Axial Spondyloarthritis: Women Are Not So Lucky.Curr Rheumatol Rep.(2018-05-12)