Family history has been identified as a significant risk factor for developing BPH. The risk of BPH is increased 4-fold in men who have a relative with BPH, and this risk increases to 6-fold if their brother has BPH.[1] Recent genetic studies have identified a “genetic signature” of BPH in which two genes — BMP5 and CXCL13 — seem to play a role in the pathogenesis of BPH.[2]
References
- ^Sanda MG, Beaty TH, Stutzman RE, Childs B, Walsh PCGenetic susceptibility of benign prostatic hyperplasia.J Urol.(1994-Jul)
- ^Middleton LW, Shen Z, Varma S, Pollack AS, Gong X, Zhu S, Zhu C, Foley JW, Vennam S, Sweeney RT, Tu K, Biscocho J, Eminaga O, Nolley R, Tibshirani R, Brooks JD, West RB, Pollack JRGenomic analysis of benign prostatic hyperplasia implicates cellular re-landscaping in disease pathogenesis.JCI Insight.(2019-05-16)