The precise causes of BPH are not well understood, but several factors — both modifiable and nonmodifiable — have been implicated, including hormones (i.e., dht, estrogen), genetics, dietary factors, inflammation, and oxidative stress.[1] According to some evidence, the risk of BPH is increased by four-fold in people with a first-degree relative with BPH.[2] Also, metabolic-syndrome is consistently associated with an increased risk of BPH,[3] so it may be involved in the development and progression of the condition.
References
- ^Ng M, Baradhi KMBenign Prostatic HyperplasiaStatPearls.(2022-05)
- ^Sanda MG, Beaty TH, Stutzman RE, Childs B, Walsh PCGenetic susceptibility of benign prostatic hyperplasia.J Urol.(1994-Jul)
- ^Omran A, Leca BM, Oštarijaš E, Graham N, Da Silva AS, Zaïr ZM, Miras AD, le Roux CW, Vincent RP, Cardozo L, Dimitriadis GKMetabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors.Ther Adv Endocrinol Metab.(2021)