Can vitamin D supplements improve bone health?

    Last Updated: October 25, 2023

    Maybe, but most likely only in people who have low vitamin D levels.

    Vitamin D is essential for calcium absorption in the small intestine. When vitamin D levels are too low, blood calcium levels fall, and more calcium is released from bones to maintain circulating calcium levels in the body. Over time, this process results in bone demineralization[1] and increases the risk of fractures. Prolonged and severe vitamin D deficiency can result in a condition known as rickets (in children) and osteomalacia (in adults), which is characterized by bone pain, soft bones, and skeletal deformities.

    Although severe vitamin D deficiency is somewhat rare in middle- and high-income countries, suboptimal vitamin D levels are not uncommon, likely because of low sun exposure (which decreases the skin’s synthesis of vitamin D) and inadequate dietary intake (very few foods naturally contain vitamin D). Thus, it is plausible that vitamin D supplementation may improve bone health in certain people, but the results to date are mixed.

    In some studies, supplementation with up to 800 IU/day of vitamin D reduced the risk of bone fractures in select individuals, such as those with low baseline levels of vitamin D and older adults.[2][3] There is also evidence that combining vitamin D supplementation with calcium may improve BMD.[4][5] Conversely, two large trials found that vitamin D supplementation had no effect on bone structure, BMD, or fracture incidence in healthy older adults.[6][7]

    References

    1. ^Laird E, Ward M, McSorley E, Strain JJ, Wallace JVitamin D and bone health: potential mechanismsNutrients.(2010 Jul)
    2. ^Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes BFracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trialsJAMA.(2005 May 11)
    3. ^Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski JPrevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trialsArch Intern Med.(2009 Mar 23)
    4. ^Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens PNeed for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials.J Clin Endocrinol Metab.(2007-Apr)
    5. ^DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) GroupPatient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and EuropeBMJ.(2010 Jan 12)
    6. ^LeBoff MS, Chou SH, Murata EM, Donlon CM, Cook NR, Mora S, Lee IM, Kotler G, Bubes V, Buring JE, Manson JEEffects of Supplemental Vitamin D on Bone Health Outcomes in Women and Men in the VITamin D and OmegA-3 TriaL (VITAL)J Bone Miner Res.(2020 May)
    7. ^Meryl S LeBoff, Sharon H Chou, Kristin A Ratliff, Nancy R Cook, Bharti Khurana, Eunjung Kim, Peggy M Cawthon, Douglas C Bauer, Dennis Black, J Chris Gallagher, I-Min Lee, Julie E Buring, JoAnn E MansonSupplemental Vitamin D and Incident Fractures in Midlife and Older AdultsN Engl J Med.(2022 Jul 28)