Evidence from twin and family studies on GERD have suggested that this condition may have about 31% heritability — meaning that a genetic influence can account for about one-third of the variation in GERD in the general population.[1] Identical twins are more likely to both have GERD than fraternal twins or non-twin family members,[2] and studies on families indicate a clear pattern of inheritance for GERD.[3] The role of specific genes in GERD has been elusive, though one study identified the C825T polymorphism in the GNB3 subunit gene as being significantly associated with GERD.[4]
References
- ^Argyrou A, Legaki E, Koutserimpas C, Gazouli M, Papaconstantinou I, Gkiokas G, Karamanolis GRisk factors for gastroesophageal reflux disease and analysis of genetic contributors.World J Clin Cases.(2018-Aug-16)
- ^Lembo A, Zaman M, Jones M, Talley NJInfluence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: a twin study.Aliment Pharmacol Ther.(2007-Jun-01)
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- ^de Vries DR, ter Linde JJ, van Herwaarden MA, Smout AJ, Samsom MGastroesophageal reflux disease is associated with the C825T polymorphism in the G-protein beta3 subunit gene (GNB3).Am J Gastroenterol.(2009-Feb)