Yes and yes. While elevated intraocular pressure is an important risk factor for the development and progression of glaucoma, not all people with elevated intraocular pressure will develop glaucoma. Moreover, many people will develop glaucoma even in the absence of elevated intraocular pressure in what is termed “normal-tension glaucoma”.[1] The implication from the above is that the amount of tolerated intraocular pressure may vary between individuals,[2] and that the pathophysiology of glaucoma is likely multifactorial; that is, factors other than intraocular pressure are involved in the development and progression of the condition.
References
- ^Killer HE, Pircher ANormal tension glaucoma: review of current understanding and mechanisms of the pathogenesis.Eye (Lond).(2018-05)
- ^Chen Y, Hughes G, Chen X, Qian S, Cao W, Wang L, Wang M, Sun XGenetic Variants Associated With Different Risks for High Tension Glaucoma and Normal Tension Glaucoma in a Chinese Population.Invest Ophthalmol Vis Sci.(2015-Apr)