There is some evidence that probiotics improve eradication rates when added to a conventional treatment regimen. Lactobacillus-containing probiotics combined with quadruple therapy (such as bismuth, antacid medication, and two antibiotics) may be the most effective combination.[1][2][3] However, another meta-analysis found that probiotics may not increase the eradication rate, but may decrease adverse effects of triple or quadruple therapy.[4]
Synbiotics (which contain both probiotic microbes and their preferred prebiotic nutrient) may also improve eradication rates while reducing adverse treatment side effects.[5]
High-dose vitamin C supplementation and antioxidant-rich cranberry juice improved the efficacy of conventional treatment in a small number of studies, but more research is needed.[6]
Supplemental vitamin E, N-acetylcysteine, and curcumin have also been studied, but they don’t appear to improve eradication rates when added to conventional treatment.[7][6]
References
- ^Shi X, Zhang J, Mo L, Shi J, Qin M, Huang XEfficacy and safety of probiotics in eradicating Helicobacter pylori: A network meta-analysis.Medicine (Baltimore).(2019-Apr)
- ^Zhang M, Zhang C, Zhao J, Zhang H, Zhai Q, Chen WMeta-analysis of the efficacy of probiotic-supplemented therapy on the eradication of H. pylori and incidence of therapy-associated side effects.Microb Pathog.(2020-Oct)
- ^Viazis N, Argyriou K, Kotzampassi K, Christodoulou DK, Apostolopoulos P, Georgopoulos SD, Liatsos C, Giouleme O, Koustenis K, Veretanos C, Stogiannou D, Moutzoukis M, Poutakidis C, Mylonas II, Tseti I, Mantzaris GJA Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates.Nutrients.(2022-Feb-01)
- ^Lu C, Sang J, He H, Wan X, Lin Y, Li L, Li Y, Yu CProbiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis.Sci Rep.(2016-Mar-21)
- ^Pourmasoumi M, Najafgholizadeh A, Hadi A, Mansour-Ghanaei F, Joukar FThe effect of synbiotics in improving Helicobacter pylori eradication: A systematic review and meta-analysis.Complement Ther Med.(2019-Apr)
- ^Yang-Ou YB, Hu Y, Zhu Y, Lu NHThe effect of antioxidants on Helicobacter pylori eradication: A systematic review with meta-analysis.Helicobacter.(2018-Dec)
- ^Caicedo Ochoa EY, Quintero Moreno CO, Méndez Fandiño YR, Sánchez Fonseca SC, Cortes Motta HF, Guio Guerra SAAssessment of the use of vitamin C and E supplements concomitantly to antibiotic treatment against Helicobacter pylori: A systematic review and meta-analysis.Med Clin (Barc).(2018-07-23)