Pharmacotherapy typically begins with a statin prescribed up to the highest tolerated dose to reach the LDL-C goal set for the individual.[1] If the LDL-C goal is not achieved with the maximum tolerated dose of a statin, combination therapy with ezetimibe is recommended.[1] If the LDL-C goal is still not met, the addition of a PCSK9 inhibitor is recommended.[1]
What are some of the main medical treatments for high cholesterol?
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•Last Updated: May 16, 2025
High cholesterol treatment begins with using the highest tolerated statin dose to reach the LDL cholesterol goal. If this goal is not met, a next step may be combination therapry with with ezetimibe and, if needed, a PCSK9 inhibitor.