Yes, MetS increases the risk of a number of conditions, including cardiovascular disease and type 2 diabetes, as well as all-cause mortality. Having MetS has been associated with the following increased health risks:
- A 253%–417% higher risk of type 2 diabetes[1]
- A 65%–118% higher risk of incident cardiovascular disease or events[2][3][4]
- A 74%–117% higher risk of cardiovascular-disease-related mortality[3][4]
- A 41%–60% higher risk of all-cause mortality[3][4]
- 150% higher odds of polycystic ovary syndrome[5][6]
- A higher risk of several cancers, including a 36% higher risk of colorectal cancer,[7], a 47% higher risk of breast cancer,[8] a 76% higher risk of liver cancer,[9] and an 89% higher risk of endometrial cancer[10]
References
- ^Ford ES, Li C, Sattar NMetabolic syndrome and incident diabetes: current state of the evidence.Diabetes Care.(2008-Sep)
- ^Ford ESRisks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.Diabetes Care.(2005-Jul)
- ^Gang Hu, Qing Qiao, Jaakko Tuomilehto, Beverley Balkau, Knut Borch-Johnsen, Kalevi Pyorala, DECODE Study GroupPrevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and womenArch Intern Med.(2004 May 24)
- ^Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, Montori VMMetabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies.J Am Coll Cardiol.(2007-Jan-30)
- ^Behboudi-Gandevani S, Amiri M, Bidhendi Yarandi R, Noroozzadeh M, Farahmand M, Rostami Dovom M, Ramezani Tehrani FThe risk of metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis.Clin Endocrinol (Oxf).(2018-02)
- ^Otaghi M, Azami M, Khorshidi A, Borji M, Tardeh ZThe association between metabolic syndrome and polycystic ovary syndrome: A systematic review and meta-analysis.Diabetes Metab Syndr.(2019)
- ^Shen X, Wang Y, Zhao R, Wan Q, Wu Y, Zhao L, Wu XMetabolic syndrome and the risk of colorectal cancer: a systematic review and meta-analysis.Int J Colorectal Dis.(2021-Oct)
- ^Bhandari R, Kelley GA, Hartley TA, Rockett IRMetabolic syndrome is associated with increased breast cancer risk: a systematic review with meta-analysis.Int J Breast Cancer.(2014)
- ^Ren H, Wang J, Gao Y, Yang F, Huang WMetabolic syndrome and liver-related events: a systematic review and meta-analysis.BMC Endocr Disord.(2019-Apr-25)
- ^Esposito K, Chiodini P, Capuano A, Bellastella G, Maiorino MI, Giugliano DMetabolic syndrome and endometrial cancer: a meta-analysis.Endocrine.(2014-Feb)