Women with PCOS and obesity were reported[1] to exhibit a significant increase in hunger one hour after an ad libitum meal in comparison to a control group that took two hours to reach significance. Interestingly, these differences did not coincide with changes in ghrelin (a hunger hormone). Even more perplexing is the fact that PCOS is associated with higher levels of leptin[2], a satiety hormone. This suggests that people with PCOS may have some form of leptin resistance. Recent research[3] is beginning to determine the mechanism for leptin resistance in PCOS.
References
- ^Camila Cremonezi Japur, Rosa Wanda Diez-Garcia, Fernanda Rodrigues de Oliveira Penaforte, Geórgia das Graças Pena, Lúcio Borges de Araújo, Marcos Felipe Silva de SáInsulin, ghrelin and early return of hunger in women with obesity and polycystic ovary syndromePhysiol Behav.(2019 Jul 1)
- ^J ChakrabartiSerum leptin level in women with polycystic ovary syndrome: correlation with adiposity, insulin, and circulating testosteroneAnn Med Health Sci Res.(2013 Apr)
- ^Teresa Vilariño-García, Antonio Pérez-Pérez, Esther Santamaría-López, Nicolás Prados, Manuel Fernández-Sánchez, Víctor Sánchez-MargaletSam68 mediates leptin signaling and action in human granulosa cells: possible role in leptin resistance in PCOSEndocr Connect.(2020 Jun)