There are no standard treatments for POTS. Rather, treatment is focused on decreasing heart rate, increasing blood volume, and/or stabilizing blood pressure. Some of the most commonly prescribed drugs include mineralocorticoids (e.g., fludrocortisone) vasopressin receptor agonists (e.g., desmopressin), beta-blockers (e.g., metoprolol and propranolol), and alpha-agonists (e.g., midodrine). One liter of normal saline given intravenously over an hour also seems to be helpful, but this therapy isn’t recommended for long-term use. [1]