Because the hallmark of T1D is insulin deficiency, the main medical treatment is multiple daily injections of prandial (i.e., with meals) and basal (i.e., background or between meals) insulin or continuous subcutaneous insulin infusion.[1] There are multiple approaches to insulin treatment, but in general, some form of insulin is given in a planned regimen tailored to the individual's unique situation to prevent DKA and avoid severe hypoglycemia while meeting their glycemic targets.[1]
In addition, adjunctive therapies to augment insulin treatment are being studied to optimize glycemic control. Pramlintide (an amylin analog) is the only option approved for use, but evidence from clinical trials suggests that common medications such as glucagon-like peptide-1 receptor agonists may also provide benefits.[2]
