The specific cause of UC is unknown. It does appear, however, that a dysfunction in the immune system causes immune cells and inflammatory molecules to damage the digestive tract. It is considered an autoimmune disease. Additionally, genetics, lifestyle, and the gut microbiome also play a role in the development of UC.[1]
What causes ulcerative colitis?
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•Last Updated: May 16, 2025
The specific cause of ulcerative colitis (UC) is unknown, but it is believed to involve a dysfunction in the immune system that leads to damage in the digestive tract. Factors such as genetics, lifestyle, and the gut microbiome also contribute to the development of UC.