Medications are generally reserved for people with osteopenia who have a particularly high risk of fractures (as determined by a clinician). People with an osteopenia T-score (−1 to −2.5) and a 10-year fracture risk of 20% or more (measured using tools like the Fracture Risk Assessment Tool, FRAX) may be started on medication to increase bone density.[1][2] These same medications are used for the treatment of more severe bone loss or osteoporosis. The most commonly used medications are bisphosphonates (risedronate, alendronate, etc.), which reduce bone breakdown; however, prolonged use can increase the risk of atypical fractures of the femur bone, and therefore continuous use is generally limited to 3 to 5 years. Other medications include estrogen and/or progestin hormone-replacement therapies, selective estrogen receptor modulators (raloxifene), calcitonin, teriparatide, and denosumab.[1][2]
Are there any other treatments for osteopenia?
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•Last Updated: May 16, 2025
Medications for osteopenia are typically prescribed for people who are at high risk of fractures, particularly those with a T-score between −1 and −2.5 and a 10-year fracture risk of 20% or more. Bisphosphonates are the most common treatment, and other options include hormone-replacement therapies, selective estrogen receptor modulators, calcitonin, teriparatide, and denosumab; prolonged use of bisphosphonates is limited to 3 to 5 years due to potential risks.