In short, it is possible. Limited research has found that chronic kratom use has been associated with dependence and opioid-like withdrawal. However, withdrawal after kratom seems to be more mild than opioid withdrawal. Withdrawal symptom severity seems to be dependent on the quantity and duration of kratom use. Symptoms can include mood disturbances (anxiety and depression), muscle spasms, pain, fever, and diarrhea. Chronic kratom users reported cravings for kratom and dependence on kratom to be able to function well throughout the day.[1][2][3]