The combination of St. John’s wort (Hypericum perforatum) and high doses of iCR appears to be more effective at improving psychological climacteric symptoms, like depression, than black cohosh alone. Furthermore, the frequency of adverse events did not significantly differ between iCR taken alone or vs. iCR in combination with St. John’s wort.[1]
Can black cohosh be taken with St. John’s wort?
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•Last Updated: May 16, 2025
Combining St. John’s wort with high doses of iCR may be more effective for improving psychological climacteric symptoms, such as depression, than black cohosh alone. Additionally, the occurrence of adverse events is similar whether iCR is taken alone or with St. John’s wort.