Can creatine treat muscle disorders?

Although curative therapies for muscle disorders are lacking, supplementation with creatine may improve the symptoms of some muscle disorders. According to a 2013 Cochrane meta-analysis, supplementation with creatine decreased symptom severity, increased muscle strength, and improved activities of daily living in individuals with muscular dystrophies.^[1] However, no effects of creatine were observed in individuals with metabolic myopathies. It’s also worth noting that one trial reported an increase in muscle pain episodes and impairment in activities of daily living with creatine in individuals with glycogen storage disease type V (GSDV, also called McArdle disease).^[2]