Can fish oil increase the risk of bleeding?

For most people, regular fish oil supplements do not affect bleeding risk. One meta-analysis of 11 randomized studies with over 80,000 patients concluded (with low certainty) that fish oil does not increase bleeding risk,^[1] and another meta-analysis, which stratified by type of fish oil supplement, reported similar findings. Interestingly, the latter meta-analysis noted that EPA-only supplements did increase bleeding risk compared to control, but the absolute increase in risk was very small: about 0.5%, suggesting that for every 200 people taking an EPA-only supplement, one might experience bleeding.^[2]