Topical and oral MSM have been used in skin products that reduce inflammation and the signs of aging, and that promote wound healing. There may be improvement in rosacea with both oral and topical MSM, and one study found that combining silymarin with MSM in a cream could improve redness, hydration, and itching in people with rosacea.[1][2] Another study found that an oral dose of 1 to 3 grams daily could improve the signs of skin aging.[3] A study done on mice showed that MSM could protect the skin against sun damage.[4] Evidence is limited for the role of MSM products in wound healing, but it is possible that the anti-inflammatory effects could play a role in the healing process. One study found that combining MSM with silk amino acids could improve wound healing.[5]
While these studies show some positive effects, there is a lack of large clinical trials to support claims that MSM could be used to treat any specific skin condition or as an antiaging product.