Can MSM help alleviate the symptoms of allergic rhinitis?

MSM might help to alleviate the respiratory symptoms of allergic rhinitis. Several studies have found that using MSM decreased the symptoms of seasonal allergies such as nasal congestion, runny nose (rhinorrhea), itching, and sneezing, and there might be an improvement in fatigue levels with MSM supplementation. Some of these studies also measured immunoglobulin E (IgE), histamine, or C-reactive protein (CRP) levels, but the changes were not statistically significant.^[1][2][3] While the evidence is mostly promising, larger clinical trials are needed to confirm these findings. However, using MSM is generally safe, and in people with severe symptoms of allergic rhinitis, a trial of MSM at 3 grams daily might be worthwhile.