Sickle cell disease is a lifelong condition, which can significantly impact the quality of life of those affected. In a 2019 study, researchers assessed 73,225 adults hospitalized for SCD to understand the prevalence of depression among them. The findings revealed that comorbid depression was more common in females aged between 35 and 50, and was associated with a higher risk of major complications and a higher cost per hospital admission.[1] However, it is important to note that this study only looked at hospitalized patients, and did not evaluate a causal relationship between SCD and depression. Nonetheless, the data suggest that incorporating mental health assessments for individuals with SCD could improve patients’ outcomes.
Can sickle cell disease impact mental health?
Written by:
Fact-checked
by:
•Last Updated: May 16, 2025
Sickle cell disease can significantly affect quality of life and is associated with a higher prevalence of depression, particularly in women aged 35 to 50. Although a study indicated this correlation, it did not establish a causal relationship, which highlights the potential benefit of including mental health assessments for people with SCD.