The phototoxicity of the psoralens found in cold-pressed bergamot essential oil, especially the psoralen bergapten, is a drawback in most situations. However, it can be medically useful in the treatment of some skin conditions, including vitiligo, eczema, and psoriasis. For example, people undergoing psoralen and UVA (PUVA) therapy take psoralens orally or apply them topically, then expose skin to UVA light. Cases of second-degree burns due to PUVA therapy have been reported; this therapy should only be done under medical supervision.[1][2]
Can the photosensitizing property of psoralens found in bergamot be medically useful?
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•Last Updated: May 16, 2025
The phototoxicity of psoralens in cold-pressed bergamot oil can be a drawback, but it is medically useful for treating skin conditions like vitiligo, eczema, and psoriasis through therapies such as psoralen-UVA. This treatment should only be conducted under medical supervision due to potential risks, including second-degree burns.