Preclinical studies on vitamin D have indicated that it may interact with and interfere with various signaling pathways associated with other neurodegenerative diseases, such as Parkinson’s disease, multiple sclerosis, and vascular dementia. Unfortunately, as with Alzheimer’s disease, the results of clinical trials of vitamin D in people with these neurodegenerative diseases have overall been mixed, although some trials have reported positive effects on disease pathology. More large-scale, multicenter clinical trials are needed to better understand when, or if, vitamin D supplementation might be indicated as part of treatment strategies for neurodegenerative disease.[1]
Can vitamin D supplementation help with the treatment or prevention of other neurodegenerative diseases?
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•Last Updated: May 16, 2025
Preclinical studies suggest that vitamin D may influence signaling pathways related to various neurodegenerative diseases, including Parkinson’s disease and multiple sclerosis. However, clinical trial results have been mixed, which indicates a need for larger studies to clarify the potential role of supplemental vitamin D in treating these conditions.