Black seed has antiviral, immune-modulating, and anti-inflammatory properties, which makes it a potential candidate for the treatment of COVID-19. Additionally, compounds in black seed might theoretically prevent SARS-CoV-2 from entering human cells by blocking the receptor the virus uses to gain entry, angiotensin-converting enzyme 2 (ACE2).[1][2]
A 2023 meta-analysis suggested that in people with COVID-19, black seed supplementation may reduce the risk of mortality and reduce the time to a negative PCR test. However, three of the seven studies included in the analysis used black seed in addition to other interventions (honey or other herbal medicines), and most trials were not blinded, which reduces our confidence in these findings.[3] Additionally, some trials using black seed or its active compound (thymoquinone) in patients with mild to moderate COVID-19 reported a faster reduction of symptoms compared to a placebo,[4][5][2] while another trial found no effect.[6]
Despite preliminary research showing potential promise, there is currently not enough evidence to reasonably recommend black seed for the treatment (or prevention) of COVID-19.