ASBs, and NNS in general, do not cause insulin to increase in the bloodstream. Hypotheses suggesting that ASBs and NNS could initiate an insulin response, by either a central or a hormonal mechanism, have not been supported by research. Multiple studies have been done showing that artificial sweeteners do not impact blood sugar or insulin levels, whether taken alone or with a meal.[1][2][3][1][4]
Do artificially sweetened beverages cause insulin spikes?
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•Last Updated: May 16, 2025
Artificially sweetened beverages and nonnutritive sweeteners do not cause an increase in insulin levels in the bloodstream. Research has consistently shown that they do not affect blood sugar or insulin levels, regardless of whether they are consumed alone or with food.