In short, yes. This is because vegetarian diets lack the main dietary source of creatine — meat. With this in mind, and considering that around half of the daily need for creatine is obtained from the diet in omnivores,[1] it’s no surprise that the muscle creatine content of individuals eating a vegetarian diet tends to be lower compared to individuals eating an omnivorous diet.[2] Supplementation with creatine appears to close this gap.[3] It’s worth noting that the levels of creatine in the brain are similar between vegetarians and omnivores.[4][5]