Black seed has anti-inflammatory and immune-modulating properties, and preclinical research suggests it may also reduce histamine release and leukotriene B4 synthesis, making it an interesting candidate for both asthma and allergic rhinitis. Clinical research is limited to a handful of small trials, but so far results have tended to be positive.
In allergic rhinitis, several trials have found reductions in symptoms (e.g., itching, sneezing, congestion, runny nose) with black seed supplementation compared to a placebo. Benefits have been demonstrated for mild, moderate, or severe allergic rhinitis with both oral and intranasal black seed.[1][2][3]
For asthma, preliminary research has reported clinically significant improvements in the Asthma Control Test scores — a validated measurement tool that considers shortness of breath, interference with daily activities, use of rescue inhalers, nighttime waking, and overall asthma control — in both children and adults with partially controlled asthma.[4][5][6] There’s also some data to suggest that black seed may have a bronchodilatory (airway-opening) effect and improve lung function, including increased forced expiratory volume in 1 second (FEV1) and peak expiratory flow rate, but this hasn’t been found consistently. [7][8][9][10]
References
- ^Nikakhlagh S, Rahim F, Aryani FH, Syahpoush A, Brougerdnya MG, Saki NHerbal treatment of allergic rhinitis: the use of Nigella sativaAm J Otolaryngol.(2011 Sep-Oct)
- ^Alsamarai AM, Abdulsatar M, Ahmed Alobaidi AHEvaluation of topical black seed oil in the treatment of allergic rhinitis.Antiinflamm Antiallergy Agents Med Chem.(2014-Mar)
- ^Ansari M, Ansari N, Junejo SMontelukast versus Nigella sativa for management of seasonal allergic rhinitis: A single blind comparative clinical trial.Pak J Med Sci.(2010 Apr)
- ^Koshak A, Wei L, Koshak E, Wali S, Alamoudi O, Demerdash A, Qutub M, Pushparaj PN, Heinrich MNigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial.Phytother Res.(2017-Mar)
- ^Salem AM, Bamosa AO, Qutub HO, Gupta RK, Badar A, Elnour A, Afzal MNEffect of Nigella sativa supplementation on lung function and inflammatory mediatorsin partly controlled asthma: a randomized controlled trial.Ann Saudi Med.(2017)
- ^Kardani A, Fitri L, Barlianto W, Olivianto E, Kusuma CThe effect of house dust mite immunotherapy, probiotic and Nigella sativa in the number of Th17 cell and asthma control test scoreIOSR J Dent Med Sci.(2013 May)
- ^Khazdair M, Amirabadizadeh ATherapeutic effects of Nigella sativa on asthma: a systematic review of clinical trialPhysiol Pharmacol.(2022 Jun)
- ^Koshak A, Koshak E, Heinrich MMedicinal benefits of in bronchial asthma: A literature review.Saudi Pharm J.(2017-Dec)
- ^Han A, Shi DThe efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies.Postepy Dermatol Alergol.(2021-Aug)
- ^Boskabady MH, Mohsenpoor N, Takaloo LAntiasthmatic effect of Nigella sativa in airways of asthmatic patients.Phytomedicine.(2010-Aug)