Does citrulline reduce blood pressure?

Citrulline supplementation has been presented as a way of lowering blood pressure due to its capacity to boost nitric oxide production, a vasodilator. One meta-analysis does suggest that supplementation with citrulline can mildly decrease blood pressure, but because the participants were limited to healthy individuals, more research is needed to see whether this decrease applies to people with high blood pressure.^[1] It’s also unclear whether certain forms (e.g., L-citrulline, citrulline malate, or citrulline from watermelon juice), higher doses (ranging from 2 to 8 grams in many studies), or increased lengths of supplementation reduce blood pressure further.