Citrulline supplementation has been presented as a way of lowering blood pressure due to its capacity to boost nitric oxide production, a vasodilator. One meta-analysis does suggest that supplementation with citrulline can mildly decrease blood pressure, but because the participants were limited to healthy individuals, more research is needed to see whether this decrease applies to people with high blood pressure.[1] It’s also unclear whether certain forms (e.g., L-citrulline, citrulline malate, or citrulline from watermelon juice), higher doses (ranging from 2 to 8 grams in many studies), or increased lengths of supplementation reduce blood pressure further.
Does citrulline reduce blood pressure?
Written by:
Fact-checked
by:
•Last Updated: May 16, 2025
Supplementation with citrulline may mildly reduce blood pressure by enhancing nitric oxide production, but more research is needed to determine its effects in people with high blood pressure. The effects of different forms, doses, and durations of supplemental citrulline on blood pressure remain unclear.