Limited evidence suggests that a single dose of creatine at rest may increase growth hormone secretion in the hours following supplementation, with a high degree of variability between individuals (38%–128%).[1] On the other hand, creatine loading (but not a lower daily dose to maintain elevated creatine levels) may blunt exercise-induced growth hormone secretion.[2]
Does creatine affect growth hormone levels?
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•Last Updated: May 16, 2025
Limited evidence indicates that a single dose of creatine may increase growth hormone secretion after supplementation, though individual responses vary significantly. Conversely, creatine loading could reduce exercise-induced growth hormone secretion.