Folic acid supplementation may have minor benefits on blood glucose regulation, but these effects are probably not clinically relevant. Research suggests that folic acid may slightly reduce fasting blood glucose, fasting insulin, and HOMA-IR (a marker of insulin resistance), but not in people with type 2 diabetes. Additionally, folic acid does not appear to affect hemoglobin A1c.[1][2][3]
Does folic acid improve blood sugar regulation?
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•Last Updated: May 16, 2025
Folic acid supplementation may have minor benefits on blood glucose regulation, fasting blood glucose, insulin, and insulin resistance markers, but these effects are likely not clinically significant and do not apply to people with type 2 diabetes. Additionally, folic acid does not appear to influence HbA1c levels.