Does kratom help manage opioid dependence?

In short, we don’t know. There is no human clinical research assessing the use of kratom for managing symptoms of opioid dependence and withdrawal. However, in a cross-sectional survey study in 136 chronic kratom users living in Malaysia, users reported taking an average of 3 glasses of kratom tea daily to reduce opioid intake and to manage withdrawal symptoms.^[1] There are also some promising preclinical studies of kratom use in mice with opioid dependence.^[2]