Does maca have any drug interactions?

Although there are no known drug interactions with maca, a comprehensive drug interaction study has not been conducted. In vitro evidence suggests that aqueous and ethanolic maca extracts have some estrogenic activity.^[1] However, it is unclear if this estrogenic activity translates to humans. Some clinical research suggests that gelatinized maca increases estradiol levels compared to placebo, while other clinical research shows no effect on hormone levels.^{[2] [3]} Therefore, it’s unknown whether maca might interfere with hormonal drug therapy. Maca does not seem to have the potential to affect drug metabolism through the liver. An in vitro screening study did not find that maca extracts are likely to inhibit or induce cytochrome P450 enzymes in the liver, but further research is needed to confirm these findings.^[4]