Many mental disorders are associated with dysregulation of the neurotransmitters glutamate and/or dopamine, as well as increased levels of oxidative stress in the brain.[1] Aside from its antioxidant effects, research shows that NAC crosses the blood-brain barrier and can directly alter glutamate neurotransmission, with an indirect effect on dopamine as well,[2] making it a potentially helpful supplement for a variety of conditions.
When used in addition to standard care, NAC has shown small benefits for the management of schizophrenia,[3][4][5] depression symptoms (including bipolar depression),[6][7] autism spectrum disorder (specifically hyperactivity and irritability),[8] and substance use disorder.[9]