Does T1D alter any other hormones?

Together with insulin, glucagon keeps the blood glucose levels of healthy individuals stable within a narrow range. When blood glucose levels go down, glucagon secretion goes up^[1] to increase blood glucose levels. As such, both pancreatic hormones are intimately linked, and the levels of one control the levels of the other directly^[2]. Therefore, it seems plausible that there might also be a dysregulation in glucagon in people with type 1 diabetes. In recent years, there has been increasing evidence that suggests glucagon secretion is dysregulated in type 1 diabetes and contributes^[3] to both hypo- and hyperglycemia. Hence, current therapeutic efforts^[4] include treating both glucagon and insulin alterations for better glycemic control.