Together with insulin, glucagon keeps the blood glucose levels of healthy individuals stable within a narrow range. When blood glucose levels go down, glucagon secretion goes up[1] to increase blood glucose levels. As such, both pancreatic hormones are intimately linked, and the levels of one control the levels of the other directly[2]. Therefore, it seems plausible that there might also be a dysregulation in glucagon in people with type 1 diabetes. In recent years, there has been increasing evidence that suggests glucagon secretion is dysregulated in type 1 diabetes and contributes[3] to both hypo- and hyperglycemia. Hence, current therapeutic efforts[4] include treating both glucagon and insulin alterations for better glycemic control.
Does T1D alter any other hormones?
Written by:
Fact-checked
by:
•Last Updated: May 16, 2025
Type 1 diabetes may lead to dysregulation of glucagon, which is closely linked to insulin and plays a role in maintaining blood glucose levels. Recent evidence suggests that this dysregulation contributes to both hypoglycemia and hyperglycemia, which has prompted therapeutic efforts to address alterations in both hormones for improved glycemic control.