Several vitamins and supplements have been studied, including vitamin D,[1] melatonin,[2] and vitamins E and C. Vitamin E, with or without vitamin C, seems to improve pain symptoms. Vitamin D also improves pain symptoms to a lesser extent. Both effects are small, but given their good safety profiles, these supplements are worth considering in conjunction with other medical interventions.[3] Melatonin has limited evidence to support its use, but it might improve pain symptoms, sleep quality, and mood symptoms in people with endometriosis.[4]
Have any supplements been studied for endometriosis?
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•Last Updated: May 16, 2025
Several vitamins and supplements — including vitamin D, melatonin, and vitamins E and C — have been studied for endometriosis, and vitamin E has shown some improvement in pain symptoms. Although vitamin D also helps with pain to a lesser extent, melatonin has limited evidence but may enhance pain, sleep quality, and mood.