On their own, protein[1], Vitamin D[2], and DHEA[3], show no effect on frailty status. One study found that milk fat globule membrane supplementation in combination with exercise improved frailty status.[4] A meta-analysis of randomized controlled trials found that a combination of protein supplementation and exercise can also mitigate the physical aspects of frailty.[5]
Have any supplements been studied for frailty?
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•Last Updated: May 16, 2025
Individual supplements like protein, vitamin D, and DHEA have shown no effect on frailty status. However, supplementation with milk fat globule membrane combined with exercise and a combination of protein supplementation and exercise have been found to improve frailty status.