Have any supplements been studied for high cholesterol?

The supplement with the largest effect on LDL-C is red yeast rice, which is an inhibitor of endogenous cholesterol synthesis and works via the same mechanism of action as statins.^[1] Other supplements that can improve LDL-C are garlic,^[2] plant sterols and stanols,^[3] and beta-glucan (a soluble fiber primarily found in oats and barley).^[4]