Several supplements have been studied and supported by strong evidence for the relief of certain IBS symptoms. Enteric-coated peppermint oil can reduce abdominal pain, and certain probiotic strains are effective for multi-symptom relief.[1][2] Polymethylsiloxane polyhydrate — an over-the-counter intestinal adsorbent — may also relieve multiple IBS symptoms.[3] One study has shown that glutamine supplementation may improve the symptoms of post-infectious IBS.[4] Prebiotics (carbohydrates used preferentially by beneficial gut microbes) aren’t clearly effective, however, and the benefits of other alternatives like traditional Chinese medicinal herbs or aloe vera need to be confirmed in higher-quality studies.[5]
Have any supplements been studied for IBS?
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•Last Updated: May 16, 2025
Several supplements — including enteric-coated peppermint oil, certain probiotic strains, and polymethylsiloxane polyhydrate — have shown strong evidence for relieving IBS symptoms. However, the effectiveness of prebiotics and other alternatives like traditional Chinese medicinal herbs and aloe vera requires further research.