Several supplements, often in combination, have been tested for their effect on macular degeneration, including vitamin C, vitamin E, zinc, lutein, and zeaxanthin.[1][2][3] Notably, one large clinical trial found that supplementation with lutein and zeaxanthin slowed disease progression among people with intermediate stage macular degeneration.[4]
Have any supplements been studied for macular degeneration?
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•Last Updated: May 16, 2025
Several supplements — including vitamin C, vitamin E, zinc, lutein, and zeaxanthin — have been studied for their effects on macular degeneration. A important clinical trial indicated that lutein and zeaxanthin supplementation can slow disease progression in people with intermediate stage macular degeneration.